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KMID : 0363919880060010020
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Journal of the Korean Society for Chemotherapy
1988 Volume.6 No. 1 p.20 ~ p.26
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Clinical Pharmacokinetics of Tobramycin in Patients with Normal Renal Function
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禹竣熙/Woo, Jun Hee
崔康元/申院均/Choe, Kang Won/Shin, Wan Gyoon
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Abstract
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For the possible avoidance of nephrotoxicity, ototoxicity and the maintenance of the most suitable serum concentration of tobramycin, an aminoglycoside, blood concentrations of tobramycin were measured during the steady-state after intermittent intravenous administration with fluorescent polarization immunoassay.
Among eleven patients with normal renal function, peak serum concentration of tobramycin was 3.97mcg/ml, trough serum concentration was 0.3meg/ml.
The pharmacokinetic parameters during the steady-state after intermitten intravenous administraton of tobramycin were studied. The half-life was 2.01 hours in average and the volume of distribution averaged 0.40 liters/kg.
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